Endocrine Abstracts

Introduction: Both subclinical hyperthyroidism and type 2 diabetes (T2D) have been associated with an increase in cardiovascular disease risk and mortality. We aimed to assess the prevalence of newly diagnosed subclinical hyperthyroidism in a cohort of patients with T2D, and also to analyse the relationships between diabetes-related characteristics and the presence of subclinical hyperthyroidism.Methods: Nine hundred and thirty-three diabetic patients wi...

Background: Exogenous hyperthyroidism is a rare cause of thyrotoxicosis. It is caused by ingestion of excessive amounts of thyroid hormone, which could be intentional or surreptitious (known as factitious thyrotoxicosis). One of the most exceptional cause is the intake of meat or sausage containing thyroid tissue, inadvertently mixed with traces of muscles and other tissues of the animal’s neck (hamburger thyrotoxicosis). The clinical symptoms are indistinguishable from o...

Background: Immune checkpoint inhibitors like monoclonal antibodies targeting programmed death 1 receptor (PD1) or its ligand (PD-L1) have shown antitumor activity in many malignancies by enhancing immune response against cancer cells resulting in significant long-lasting responses. However, this therapy can induce endocrine immune-related adverse events (EirAEs). Thyroid dysfunction is a common EirAE, while adrenal insufficiency (AI) is very uncommon.Ob...

Introduction: Nivolumab is an antibody that binds to and blocks the activation of programmed-death-receptor 1(PD-1), promoting the activation of T-cells against tumor cells. Thyroid dysfunction (TD) is one of the most common immuno-related adverse events, with incidence up to 10% in patients treated with PD-1/PD-L1 blockade.Objective: To report our experience of Nivolumab-TD in patients with advanced cancer.Methods: All patients di...

Methods: A prospective study in 35 patients hospitalized for AKI for two consecutive years was carried out. TFT (serum thyrotropin, TSH; free thyroxine, FT4; and total triiodothyronine, T3 concentrations) were measured in each patient on three occasions: at admission, at hospital discharge and at their first outpatient visit.Results: Total prevalence of alterations in TFT was 82.9% (n=29). Of those, euthyroid sick syndrome (E...

Background: Adrenocortical carcinoma (ACC) is a rare and aggressive neoplasm with a 5-year survival rate <30%. Survival depends mainly on the stage at diagnosis, being surgery the only curative treatment.Objective: To report the clinical features, management and outcomes of a series of ACC in two Spanish tertiary hospitals.Material and methods: All patients with pathological diagnosis of ACC between 2000 and 2017 were included ...